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Abstract #2243

Identifying the Ischaemic Penumbra by Probing Tissue Metabolism and Imaging Changes in Tissue Lactate.

William Matthew Holmes1, Maria Rosario Lopez Gonzalez2, Lindsay Gallagher1, Graeme A. Deuchar1, I M. Macrae1, Celestine Santosh3

1GEMRIC, Wellcome Surgical Institute, Univeristy of Glasgow, Glasgow, United Kingdom; 2SINAPSE, Clinical Physics, University of Glasgow, Glasgow, United Kingdom; 3Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom

One of the most important considerations when treating acute stroke patients is to establish whether potentially salvageable (penumbral) tissue is still present within the brain. Currently perfusion-diffusion mismatch MRI is used, which is an indirect measure lacking precision . Here we propose a new MRI method for imaging the ischaemic penumbra based on the brains capacity to use lactate as a metabolic substrate. Spectroscopic imaging is used to map the changes in tissue lactate induced by giving a challenge of 100% oxygen.