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Abstract #2244

Estimation of the Onset Time of Cerebral Ischemia in Rats Using T1ρ MRI

Kimmo T. Jokivarsi1, Yrj Hiltunen2, Heidi I. Grhn3, Olli H. Grhn1, Risto A. Kauppinen4

1Department of Neurobiology, A.I.Virtanen -Institute, Kuopio, Finland; 2Department of Environmental Science, University of Kuopio, Kuopio, Finland; 3Department of Clinical Physiology, Nuclear Medicine and Neurophysiology, North Karelia Central Hospital, Joensuu, Finland; 4Department of Radiology, Dartmouth Medical School, Hanover, NH, United States

MRI parameters can be used to acquire information about stroke and its progression. We investigated the prediction potential of absolute T in cerebral ischemia in a rat stroke model. Our results show that δT can give an accurate estimate of ischemia time. Clinically this method provides an easy and fast MR method for ischemia time estimation that can be used in the absence of a priori knowledge or as an additional confirmation for the clinical estimate of stroke onset.