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Abstract #2285

Interictal Anomalies in Patients with Migraine Without Aura: Absence of Hemodynamic Refractory Effects

Benedicte Descamps1,2, Pieter Vandemaele1,2, Harmen Reyngoudt1,2, Karel Deblaere1,2, Luc Leybaert3, Koen Paemeleire3,4, Eric Achten1,2

1Radiology, Ghent University, Ghent, Belgium; 2GIfMI, Ghent, Belgium; 3Basic Medical Sciences, Ghent University, Ghent, Belgium; 4Neurology, Ghent University Hospital, Ghent, Belgium

In this study, single subject net hemodynamic responses to paired stimuli from patients with migraine without aura and controls are fitted using inverse logit functions and compared. We demonstrate that patients with migraine without aura do not show a decrease in amplitude of their interictal hemodynamic response to a second stimulus in a pair with 1 second interstimulus interval, whereas the control group shows hemodynamic refractory effects when looking at repetitive stimuli. The finding in this patient group may be the neurovascular correlate of the absence of electrophysiological habituation.