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Abstract #2286

Functional Connectivity After Fronto-Occipital Impact Mild Traumatic Brain Injury

Elena Shumskaya1,2, Teuntje Andriessen2, David Norris1,3, Pieter Vos2

1Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Gelderland, Netherlands; 2Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Erwin L. Hahn Institute for Magnetic Resonance, Essen, Germany

The objective of this study is to evaluate the alterations in the whole-brain functional connectivity after fronto-occipital impact mild traumatic brain injury (MTBI). We used the resting state fMRI to relate the cognitive deficits occurring after frontal-occipital impact MTBI to the disruptions in functional connectivity. We found the disintegration of prefrontal, temporal and parietal regions in resting-state networks of MTBI patients and showed that the disconnection between prefrontal regions underlies the decline in the rate of information processing.