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Abstract #2296

Identification of Hyperactive Intrinsic Amygdala Network Associated with Impulsivity in Abstinent Heroin Addicts

Chunming Xie1, Liping Fu2, Lin Ma3, Wenjun Li1, Alex Cohen1, Zheng Yang2, Shi-Jiang Li1

1Medical College of Wisconsin, Milwaukee, WI, United States; 2Beijing Institute of Basic Medical Science, Beijing, China; 3Department of Radiology, The PLA General Hospital, Beijing, China

The purpose of this study was to investigate the neuropsychological underpinnings of impulsive network on abstinent heroin addicts using resting-state functional connectivity method. Heroin subjects showed the higher impulsive scores and abnormal amygdala networks activity. The altered amygdala network strengths significantly correlated with impulsivity, and different correlation patterns were fund in heroin subjects relative to control subjects. This finding indicated the neural constructs of impulsive network was different in these two group subjects and altered amygdala network activity in heroin subjects makes a critical contribution to the impulsive dysfunction and represents the pathological damage underlying the impulsive control.