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Abstract #2300

Occupational Solvent Exposure and Working Memory Function

David Matthew Carpenter1, Emily L. Eaves1, Cheuk Ying Tang1, Gudrun Lange2,3, Johnny Ng4, Nancy L. Fiedler5

1Radiology, Mount Sinai School of Medicine, New York, United States; 2Psychiatry, UMDNJ-New Jersey Medical School, Newark, NJ; 3Radiology, UMDNJ-New Jersey Medical School, West Orange, NJ, United States; 4Radiology, City Colege ofl New York, Bronx, NY, United States; 5Environmental and Occupational Medicine, UMDNJ- Robert Wood Johnson Medical School, Piscataway, NJ, United States

In this report BOLD fMRI to investigate the functional deficits of subjects with long-term occupational solvent exposure. Subjects underwent fMRI while performing a Sternberg task and N-back working memory task. We used an exploratory voxel-wise and an ROI analysis to test the hypothesis that the occupationally exposed subjects show hypo-activation in regions associated with working memory when compared to a carefully matched control group. the results suggest that prolonged occupational solvent exposure is related to a decreased activation in regions associated with working memory.