David Matthew Carpenter1, Emily L. Eaves1,
Cheuk Ying Tang1, Gudrun Lange2,3, Johnny Ng4,
Nancy L. Fiedler5
1Radiology, Mount Sinai School of
Medicine, New York, United States; 2Psychiatry, UMDNJ-New Jersey
Medical School, Newark, NJ; 3Radiology, UMDNJ-New Jersey Medical
School, West Orange, NJ, United States; 4Radiology, City Colege
ofl New York, Bronx, NY, United States; 5Environmental and
Occupational Medicine, UMDNJ- Robert Wood Johnson Medical School, Piscataway,
NJ, United States
In
this report BOLD fMRI to investigate the functional deficits of subjects with
long-term occupational solvent exposure. Subjects underwent fMRI while
performing a Sternberg task and N-back working memory task. We used an exploratory voxel-wise and an
ROI analysis to test the hypothesis that the occupationally exposed subjects
show hypo-activation in regions associated with working memory when compared
to a carefully matched control group.
the results suggest that prolonged occupational solvent exposure is
related to a decreased activation in regions associated with working memory.
Keywords