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Abstract #2345

Quantitative Measurements of Cerebral Oxygen Extraction Fraction for Rabbits with Carotid Occlusion Using MRI

Xiaodong Zhang1, Chao He2, Lihong Hui3, Xiaoying Wang, 1,3, Sheng Xie3, Jiangxi Xiao3, Hongyu An4, Jue Zhang1,2, Jing Fang1,2

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2College of Engineering, Peking University, Beijing, China; 3Dept.of Radiology, Peking University First Hospital, Beijing, China; 4Dept. of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Cerebral oxygen extraction factor (OEF) provides critically important information to assess the brain oxygen metabolism in both normal and disease states. It has been reported that the OEF could be evaluated for healthy human volunteers using MRI. In this study, a based gradient echo sampling of the spin echo (GESSE) sequence implemented on GE 3.0T scanner to evaluate the cerebral OEF distribution of rabbits before and after carotid artery occlusion operation. Our study demonstrated a consistent and significant increase of OEF in rabbits post carotid artery occlusion, suggesting that this MR based method can be utilized to detect pathophysiological changes in cerebral oxygenation.