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Abstract #2346

Myelin Water Imaging of Children with Diverse Reading Ability

Eugene Yip1, Pauline Low2, Burkhard Mdler, 1,3, Catherine Lebel4, Christian Beaulieu4, Linda Siegel2, Alex Mackay1

1Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada; 2Department of Education and Counselling Psychology, and Special Education, University of British Columbia, Vancouver, British Columbia, Canada; 3Philips Medical Systems; 4Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada


Magnetic resonance imaging provides a mean to non-invasively investigate the neurological cause of dyslexia, a learning disability that affects ones ability to read despite adequate intelligence. Myelin water imaging, based on calculating the myelin water fraction from multi-echo T2 relaxation curves, can be used to quantitatively assess white matter. In this study, myelin water imaging and cognitive and reading assessments were performed on children with a wide range of reading ability in order to investigate the relationship between dyslexia and white matter development in the brain.

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