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Abstract #2351

Comparing Magnetic Susceptibility Mapping with SWI for Targeting Structures for Deep Brain Stimulation

Karin Shmueli1, Ruth O'Gorman2,3, David Lythgoe4, Michael Samuel5, Richard Selway6, Keyoumars Ashkan6, Jozef Jarosz2

1Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; 2Department of Neuroradiology, King's College Hospital, London, United Kingdom; 3MR-Zentrum, University Childrens Hospital, Zurich, Switzerland; 4Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, United Kingdom; 5Department of Neurology, King's College Hospital, London, United Kingdom; 6Department of Neurosurgery, King's College Hospital, London, United Kingdom

Susceptibility-Weighted Imaging (SWI) improves the visibility of target structures (globus pallidus (GP) and subthalamic nucleus (STN)) for deep brain stimulation (DBS). However, because phase contrast is non-local and orientation dependent, SWI contains artifacts that may result in targeting errors. Susceptibility maps, which have shown promise for overcoming such artifacts, were calculated from clinical 1.5-T phase data acquired at a single orientation. 2-mm shifts in the superior borders of the red nuclei and GP in the SWI relative to the susceptibility maps were observed in several volunteers and DBS patients showing that susceptibility mapping may help reduce SWI targeting errors.