Joao MN Duarte1, Anita Kulak2, Kim Q. Do2, Rolf Gruetter1,3
1Center for Biomedical Imaging (CIBM), Lausanne, Vaud, Switzerland; 2Centre for Psychiatric Neuroscience, Lausanne Univ. Hosp., Lausanne, Switzerland; 3Department of Radiology, Universities of Lausane and Geneva, Lausanne, Switzerland
The present study reports alterations of the neurochemical profile in the cortex of a mouse model of redox deregulation induced by genetic reduction of glutathione synthesis. The observed metabolic alterations suggest impaired mitochondrial metabolism and eventually altered neurotransmission, both possibly triggering degeneration.