Meeting Banner
Abstract #2358

Developmental in Vivo 1H NMR Spectroscopy at 14.1 T in Mice with Genetic Redox Dysregulation: An Animal Model with Relevance to Schizophrenia

Joao MN Duarte1, Anita Kulak2, Kim Q. Do2, Rolf Gruetter1,3

1Center for Biomedical Imaging (CIBM), Lausanne, Vaud, Switzerland; 2Centre for Psychiatric Neuroscience, Lausanne Univ. Hosp., Lausanne, Switzerland; 3Department of Radiology, Universities of Lausane and Geneva, Lausanne, Switzerland

The present study reports alterations of the neurochemical profile in the cortex of a mouse model of redox deregulation induced by genetic reduction of glutathione synthesis. The observed metabolic alterations suggest impaired mitochondrial metabolism and eventually altered neurotransmission, both possibly triggering degeneration.