Meeting Banner
Abstract #2362

MR Biomarkers of Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease

Ryan Chamberlain1, Malgorzata Marjanska1, Gregory Preboske2, Linda Kotilinek3, Thomas M. Wengenack4, Joseph F. Poduslo4, Karen H. Ashe3, Michael Garwood1, Clifford R. Jack2

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Department of Radiology, Mayo Clinic, Rochester, MN, United States; 3Department of Neurology, University of Minnesota, Minneapolis, MN, United States; 4Departments of Neurology, Neuroscience, and Biochemistry, Mayo Clinic, Rochester, MN, United States

The histological abnormalities that characterize Alzheimers disease are commonly divided into three major classes: amyloid plaques, neurofibrillary tangles and neurodegeneration. Much work has been done to image amyloid plaques using the APP/PS1 mouse model. However, the APP/PS1 model was developed to study amyloid plaques, and neurodegenerative changes are minimal in this model. The Tg4510 mouse model recapitulates neurodegeneration mediated through over expression of mutant human tau. In this work we compare the ability of various MR techniques (volume, T1ρ, T2ρ, ADC, FA) to detect neurodegeneration in the Tg4510 mouse model compared to wild-type mice.