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Abstract #2363

Regional Metabolic Alteration of Alzheimers Disease in the Mouse Brain Expressed as Mutant Human APP-PS1 Using 1H HR-MAS

Dong-Cheol Woo1, Sung-Ho Lee2, Do-Wan Lee1, Sang-Young Kim1, Goo-Young Kim1, Hyang-Shuk Rhim1, Chi-Bong Choi3, Hwi-Yool Kim2, Chang-Wook Lee1, Bo-Young Choe1

1The Catholic University of Korea, Seoul, Korea, Republic of; 2Konkuk university of Korea; 3Kyung-Hee University of Korea, Seoul, Korea, Republic of

This study was to investigate the regional neurochemical profile of APP-PS1 in the mouse brain of early-stage Alzheimers disease (AD) using 1H HR-MAS. Compared to the wild-type mice, the memory index (MI, behavioral test result) of the APP-PS1 mice at 18 weeks was not significantly different; however, the MI of the APP-PS1 mice at 35 weeks was significantly lower. The results of 1H HR-MAS showed that the [NAA+ Acet] level of the APP-PS1 mice decreased in the hippocampus and temporal cortex, mIns and sIns level was increased in the entire brain which are frontal, occipital, parietal cortex, hippocampus and thalamus.