Dong-Cheol Woo1, Sung-Ho Lee2,
Do-Wan Lee1, Sang-Young Kim1, Goo-Young Kim1,
Hyang-Shuk Rhim1, Chi-Bong Choi3, Hwi-Yool Kim2,
Chang-Wook Lee1, Bo-Young Choe1
1The Catholic University of Korea,
Seoul, Korea, Republic of; 2Konkuk university of Korea; 3Kyung-Hee
University of Korea, Seoul, Korea, Republic of
This
study was to investigate the regional neurochemical profile of APP-PS1 in the
mouse brain of early-stage Alzheimers disease (AD) using 1H HR-MAS.
Compared to the wild-type mice, the memory index (MI, behavioral test result)
of the APP-PS1 mice at 18 weeks was not significantly different; however, the
MI of the APP-PS1 mice at 35 weeks was significantly lower. The results of 1H
HR-MAS showed that the [NAA+ Acet] level of the APP-PS1 mice decreased in the
hippocampus and temporal cortex, mIns and sIns level was increased in the
entire brain which are frontal, occipital, parietal cortex, hippocampus and
thalamus.
Keywords