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Abstract #2368

Assessing Lysosomal Pathology Using Magnetic Resonance Imaging

Yuan Mei1, Robia G. Pautler2

1Department of Psychology, Rice University, Houston, TX, United States; 2Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, United States

There are many neurodegenerative diseases that cause lysosomal pathology including Alzheimers and Sandhoff disease. In these disorders, cellular irregularities disrupt the lysosomal membrane and cause the organelle to lose its internal acidity. Using a convertible T1 contrast agent sensitive to acidity, we hypothesize that magnetic resonance imaging (MRI) can be used to detect lysosome membrane permeabilization and loss of acidity in mouse models with lysosomal pathology. If successful, this methodology can potentially be applied in vivo and used as a tool to improve current diagnostic methods for neurological disorders such as Alzheimers disease.