Meeting Banner
Abstract #2369

Tract-Based Spatial Statistics (TBSS) Analysis Reveals Novel Changes in Lateral Thalamic Nuclei of Kainic Acid Treated Rats - Comparison of DTI and Histology

Alejandra Sierra1, Kimmo Lehtimki1,2, Teemu Laitinen1, Lassi Rieppo3,4, Asla Pitknen1,5, Olli Grhn1

1Department of Neurobiology, A.I. Virtanen for Molecular Sciences, University of Kuopio, Kuopio, Finland; 2Cerebricon Ldt., Kuopio, Finland; 3Department of Physics, University of Kuopio, Kuopio, Finland; 4Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland; 5Department of Neurology, Kuopio University Hospital, Kuopio, Finland

Diffusion tensor imaging (DTI) in combination with tract-based spatial statistics (TBSS) analysis provides valuable anatomical information about changes in brain areas contributing to epileptogenic process. Lateral thalamic nuclei are one of the areas highlighted in TBSS showing increased FA 6 months after status epilepticus in rats. The present work is focused to characterize the interrelationship of histopathological changes and ex vivo DTI in combination with TBSS analysis using several histological stainings and polarized light microscopy.