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Abstract #2370

Brain Behavior Relationship in Wild-Type Mice and a Mouse Model of Huntingtons Disease

Jurgen Germann1, Jeffrey B. Carroll2, Christine Laliberte1, R. M. Henkelman1, Michael R. Hayden2, Jason P. Lerch1

1The Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

We examined brain-behavior correlations in mice using MRI and 4 behavioural tests: Rotarod, Forced-Swim, Pre-pulse-Inhibition and Open Field test. Secondly, we investigated how these relationships are altered in a Huntingtons disease (HD) mouse model. Strong correlations were found in the wild-type mice identifying functional networks related to motor function, stress and anxiety, cortical gating and memory. The correlations are an expression of learning induced structural changes and provide insight into the study of brain networks controlling behavior; their absence in the HD mice could provide some insight into disease processes as they interfere with the changes normally induced by learning.