Abstract #2372

Areas of Susceptibility of the Predisposed Immature Rat Brain to Hyperthermic Seizures and Resultant Neurodevelopment Delay : An MRI and PET Study

Olivier Clerk-Lamalice¹, Pierre Gravel², Luc Tremblay¹, Roger Lecomte¹, Lionel Carmant^3,4, Martin Lepage¹

¹Centre dimagerie molculaire de Sherbrooke, Universit de Sherbrooke, Sherbrooke, Quebec, Canada; ²Dpartement de radiologie, Hpital Notre-Dame du Centre Hospitalier de l'Universit de Montral, Montreal, Quebec, Canada; ³Centre de recherche de lhpital Sainte-Justine, Universit de Montral, Montreal, Quebec, Canada; ⁴Groupe de recherche sur le systme nerveux central, Universit de Montral, Montreal, Quebec, Canada

A new animal model has been developed to study the relation between cortical dysplasia, hyperthermic seizure (HS) and temporal lobe epilepsy (TLE). In this study, volumetric MRI, T2-weighted signal intensity and PET were used to better understand the neurodevelopmental changes that occur after HS in a predisposed brain and a possible link with the development of TLE. Our results suggest a causal relationship between a T2-weighted signal change resulting from metabolism/vascularisation imbalance after HS and a consequent developmental delay of the hippocampus.