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Abstract #2372

Areas of Susceptibility of the Predisposed Immature Rat Brain to Hyperthermic Seizures and Resultant Neurodevelopment Delay : An MRI and PET Study

Olivier Clerk-Lamalice1, Pierre Gravel2, Luc Tremblay1, Roger Lecomte1, Lionel Carmant3,4, Martin Lepage1

1Centre dimagerie molculaire de Sherbrooke, Universit de Sherbrooke, Sherbrooke, Quebec, Canada; 2Dpartement de radiologie, Hpital Notre-Dame du Centre Hospitalier de l'Universit de Montral, Montreal, Quebec, Canada; 3Centre de recherche de lhpital Sainte-Justine, Universit de Montral, Montreal, Quebec, Canada; 4Groupe de recherche sur le systme nerveux central, Universit de Montral, Montreal, Quebec, Canada

A new animal model has been developed to study the relation between cortical dysplasia, hyperthermic seizure (HS) and temporal lobe epilepsy (TLE). In this study, volumetric MRI, T2-weighted signal intensity and PET were used to better understand the neurodevelopmental changes that occur after HS in a predisposed brain and a possible link with the development of TLE. Our results suggest a causal relationship between a T2-weighted signal change resulting from metabolism/vascularisation imbalance after HS and a consequent developmental delay of the hippocampus.