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Abstract #2373

Cerebral Blood Volume Mapping of Macro- And Microvasculature in Mouse Brain with 3D Gradient Echo MRI

Valerio Zerbi1, Diane Jansen1, Andor Veltien2, Amanda Kiliaan1, Arend Heerschap2

1Anatomy, UMC St. Radboud, Nijmegen, Netherlands; 2Radiology, UMC St. Radboud, Nijmegen, Netherlands

Impaired cerebral macro- and microvascular perfusion play an important role in the development of Alzheimers disease(AD). Here, a post-processing method is evaluated to distinguish and quantify cerebral blood volume(CBV) in macro- and microvasculature with contrast-enhanced MRI in a transgenic mouse model for AD. A comparison between steady-state CBV computations is presented, and histogram analysis is used to separate between vascular compartments. Results showed a decrease in hippocampal microvascular CBV as consequence of aging and genotyping that is not visible without separation of vascular compartments for macro- and microvasculature perfusion.