Meeting Banner
Abstract #2377

Sub-Type Specific Hippocampal Glutamate Levels in the Chronic Mild Stress Rat Model for Depression

Adriaan Campo1, Ove Wiborg2, Helene Benveniste3, Annemie Van Der Linden1

1Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium; 2Center for psykiatrisk forskning, rhus Universitetshospital Risskov, Risskov, rhus, Denmark; 3Medical Department, Brookhaven National Laboratory, Upton, NY, United States

MR spectroscopy was used to assess neurochemical changes in the hippocampus of the CMS rat model for depression. Besides the well known anhedonic phenotype, and control animals, a third group of animals was included: so-called stress resilient animals. These animals show different symptoms when subjected to prolonged stress. We suppose that these different sings of depression are due to different modulation of the HPA axis, as assessed by glutamate levels in the hippocampus: normal stressed animals show higher glutamate concentration, while the abnormal subgroup shows similar glutamate concentration as the control animals.