Abstract #2381

Cerebral Metabolite Assessment in Low and High Capacity Running Rats Using 1H-MRS

Steven R. Roys^1,2, Anjaneyulu Murugundla³, Su Xu¹, Aurora Anderson³, Jiachen Zhuo¹, Mark Limsam³, J Choi³, Lauren Koch⁴, Steve Britton⁴, Krish Chandrasekaran³, Paul Yarowsky⁵, James Russell³, Rao P. Gullapalli^1,2

¹Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; ²Core for Translational Research in Imaging @ Maryland (C-TRIM); ³Neurology, University of Maryland School of Medicine, Baltimore, MD, United States; ⁴Anesthesiology, University of Michigan, Ann Arbor, MI; ⁵Experimental Therapeutics and Pharmacology, University of Maryland School of Medicine, Baltimore, MD, United States

Very little is understood regarding CNS changes that lead to various cognitive impairments among people with impaired glucose tolerance. Even less is understood regarding the differences between high performing diabetic patients versus the low performing diabetics. The purpose of this study was to examine the neurochemical profile differences between low capacity runner rats (LCR) and high capacity runner rats (HCR) using proton magnetic resonance spectroscopy at 7.0 Tesla. Findings suggest that LCR rats have elevated taurine, myo-inositol, glutamate and choline containing compounds compared to HCR rats consistent with similar findings in diabetic patients.