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Abstract #2382

Effect of Lactate on FMRI Responses Under Hypoglycemia

Lihong Jiang1, Basavaraju G. Sanganahalli1, Peter Herman1, Raimund Herzog1, Robert Sherwin1, Fahmeed Hyder1, Douglas Rothman1, Kevin Behar1

1Yale University, New Haven, CT, United States

We investigated BOLD responses to forepaw stimulation under insulin-induced acute hypoglycemic condition, as well as effect of lactate infusion under hypoglycemia condition. All high field fMRI experiments were conducted in α-chloralose anesthetized rats. The magnitude of the BOLD response in primary somatosensory (S1FL) region decreased from euglycemic to hypoglycemic conditions. Upon lactate infusion, under hypoglycemic condition, transiently increased S1 activities, but also recruited regions beyond S1FL. These results will benefit the understanding of brain function and metabolism, as well as the role of alternative fuels under hypoglycemic condition.