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Abstract #2391

In Vivo 1H MRS Measurements of Acetate in Mouse Striatum After Permanent Focal Middle Cerebral Artery Occlusion

Hongxia Lei1,2, Lijing Xin1, Carole Berthet3, Lorenz Hirt3, Rolf Gruetter1,4

1LIFMET, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Radiology, University of Lausanne, Lausanne, Switzerland; 3Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 4Radiology, University of Geneva, Geneva, Switzerland

1H MRS of permanent focal middle cerebral occlusion (pMCAO) in mice could be feasible at high magnetic field. However, one of hydrolytic metabolites of NAA, acetate (1.9ppm), was heavily overlapped by accumulated GABA (1.89ppm) after pMCAO. In this study, we demonstrated that short echo time 1H MRS of measuring acetate was feasible at ultra short echo time using LCModel analysis when comparing to the measurements with minimal GABA contributions at a moderate echo time.