Hongxia Lei1,2, Lijing Xin1,
Carole Berthet3, Lorenz Hirt3, Rolf Gruetter1,4
1LIFMET, Ecole Polytechnique Fdrale
de Lausanne, Lausanne, Switzerland; 2Radiology, University of
Lausanne, Lausanne, Switzerland; 3Neurology, Centre Hospitalier
Universitaire Vaudois, Lausanne, Switzerland; 4Radiology,
University of Geneva, Geneva, Switzerland
1H
MRS of permanent focal middle cerebral occlusion (pMCAO) in mice could be
feasible at high magnetic field. However, one of hydrolytic metabolites of
NAA, acetate (1.9ppm), was heavily overlapped by accumulated GABA (1.89ppm)
after pMCAO. In this study, we demonstrated that short echo time 1H
MRS of measuring acetate was feasible at ultra short echo time using LCModel
analysis when comparing to the measurements with minimal GABA contributions
at a moderate echo time.