Abstract #2391

In Vivo 1H MRS Measurements of Acetate in Mouse Striatum After Permanent Focal Middle Cerebral Artery Occlusion

Hongxia Lei^1,2, Lijing Xin¹, Carole Berthet³, Lorenz Hirt³, Rolf Gruetter^1,4

¹LIFMET, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; ²Radiology, University of Lausanne, Lausanne, Switzerland; ³Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; ⁴Radiology, University of Geneva, Geneva, Switzerland

¹H MRS of permanent focal middle cerebral occlusion (pMCAO) in mice could be feasible at high magnetic field. However, one of hydrolytic metabolites of NAA, acetate (1.9ppm), was heavily overlapped by accumulated GABA (1.89ppm) after pMCAO. In this study, we demonstrated that short echo time ¹H MRS of measuring acetate was feasible at ultra short echo time using LCModel analysis when comparing to the measurements with minimal GABA contributions at a moderate echo time.