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Abstract #2390

In Vitro Proton MRS of Cerebral Metabolites in a Mouse Model of Alzheimer's Disease

Duncan Forster1, Steve Williams2, Mike James3, Jill Richardson3

1University of Manchester, Manchester, United Kingdom; 2University Of Manchester; 3GlaxoSmithKline

An in vitro proton MRS study was carried out on mice ranging from 3 to 18 months in order to investigate cerebral metabolic differences between TASTPM Alzheimer's mice and their wild type base strain. An effect of genotype was observed for myo-inositol, with concentration being higher in TASTPM mice, myo-inositol may therefore be an Alzheimer's marker. Lower levels of succinate were observed in TASTPM mice, being an effect of both age and genotype. This may indicate impaired neuronal energy production or mitochondrial dysfunction. The results also call into question the use of creatine as a reference metabolite.