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Abstract #2389

In Vivo Evidence for Ketamine-Induced Neurochemical Changes in Rat Prefrontal Cortex: An Animal Model of Schizophrenia

Sang-Young Kim1, Hyun-Sung Lee2, Eunjung Bang2, Hyun-Ju Kim2, Sung-Ho Lee3, Do-Wan Lee1, Dong-Cheol Woo1, Chi-Bong Choi4, Bo-Young Choe1

1Department of Biomedical Engineering, The Catholic University of Korea, Seoul, Korea, Republic of; 2Korea Basic Science Institute, Korea, Republic of; 3Department of Veterinary Surgery, Konkuk University, Seoul, Korea, Republic of; 4Department of Radiology, Kyunghee University Medical Center, Seoul, Korea, Republic of

The ketamine, a NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms similar to schizophrenia. In this study, we used in vivo and in vitro 1H-NMR spectroscopy to examine the brain metabolism of rat treated with subanesthetic dose of ketamine. In vivo data for Glu/Gln abnormalities in ketamine-treated rats may support the hypotheses of glutamate dysfunction for schizophrenia. In addition lower metabolic level of NAA in rats treated with ketamine may indicate reduced neuronal viability. Therefore our findings suggest that the neurochemical alterations induced by ketamine may provide the foundation for pathophysiological models of schizophrenia.