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Abstract #2406

Measurement of the Effects of Different Anesthetics in the Rat Thalamus by in Vivo 1H NMR Spectroscopy at 1

Sung-Tak Hong1, Chi-Bong Choi2, Rolf Pohmann1

1High-Field Magnetic Resonance Center , Max-Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany; 2Department of Radiology, Kyung Hee University Medical Center, Hoekidong, Seoul, Korea, Republic of

The effect of different anesthetic agents was investigated in the rat brain by using in vivo 1H NMR spectroscopy. A volume-of-interest was placed in thalamus under two different anesthesia, isoflurane and ketamine/xylazine. The significant increase of glucose was observed in a deep ketamine/xylazine anesthesia while additional metabolic variations on ascorbate, aspartate, glutathione and lactate were detected.