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Abstract #2407

Differential Neurochemical Responses in the Rat Striatum with Isoflurane or Ketamine/xylazine Anesthesia: In Vivo Proton MRS Study at 16.4 T

Chi-Bong Choi1, Sung-Tak Hong2, Sang-Young Kim3, Dong-Cheol Woo3, Bo-Young Choe3, Kyung-Nam Ryu1, Eun-Hee Kang1, Sung-Vin Yim1, Do-Wan Lee3, Rolf Pohmann2

1Kyung Hee University of Korea, Seoul, Korea, Republic of; 2Max Planck Institue for Biological Cybernetics; 3The Catholic University of Korea

This study was to evaluate alterations in striatum metabolites of rats between anesthetized with isoflurane and ketamine/xylazine in vivo 1H-MRS at 16.4T, and to investigate the appropriateness of anesthetic agents. The concentrations of Ala, Asc, Asp, GABA, Gly and PCr were significantly different between isoflurane and ketamine/xylazine induced groups at the striatum. We demonstrated that metabolites in specific brain region can be differentially influenced according to anesthetic agents. This study showed that the choice of anesthetic is significant in the setting of 1H-MRS. Appropriate anesthetic choice should be pursued to exclude the effect of anesthetic agents on the target area.