Abstract #2407
Differential
Neurochemical Responses in the Rat Striatum with Isoflurane or
Ketamine/xylazine Anesthesia: In Vivo Proton MRS Study at 16.4 T
Chi-Bong Choi1, Sung-Tak Hong2,
Sang-Young Kim3, Dong-Cheol Woo3, Bo-Young Choe3,
Kyung-Nam Ryu1, Eun-Hee Kang1, Sung-Vin Yim1,
Do-Wan Lee3, Rolf Pohmann2
1Kyung Hee
University of Korea, Seoul, Korea, Republic of; 2Max Planck
Institue for Biological Cybernetics; 3The Catholic
University of Korea
This
study was to evaluate alterations in striatum metabolites of rats between
anesthetized with isoflurane and ketamine/xylazine in vivo 1H-MRS at 16.4T,
and to investigate the appropriateness of anesthetic agents. The
concentrations of Ala,
Asc, Asp, GABA, Gly and PCr were significantly different between isoflurane
and ketamine/xylazine induced groups at the striatum. We demonstrated that
metabolites in specific brain region can be differentially influenced
according to anesthetic agents. This study showed that the choice of
anesthetic is significant in the setting of 1H-MRS. Appropriate anesthetic
choice should be pursued to exclude the effect of anesthetic agents on the
target area.
