Gunja P. Parikh1, Maxim Bester1,2,
Mariana Lazar1, James S. Babb1, Hina Jaggi1,
Laura Miles1, Robert Grossman1, Matilde Inglese3,4
1Radiology, New York University, New
York, NY, United States; 2Neuroradiology, Eppendorf-Hamburg
University, Hamburg, Germany; 3Radiology , New York University,
New York, NY, United States; 4Neurology, New York University, New York, NY, United States
Diffusion
tensor tractography provides the possibility to reconstruct fiber bundles and
to focus on regions that might play a major role in the development of
clinical deficits in patients with multiple sclerosis (MS). We used
tractography to determine whether tissue damage in the corpus callosum (CC)
and in the anterior-thalamic tracts (AT) is associated with cognitive
dysfunction and fatigue in patients with benign MS (BMS) and clinically
isolated syndrome (CIS). Differences from controls were observed in the CC
and AT tracts of BMS and CIS patients. A significant association was found
between DTI metrics in the CC and cognitive deficits.
Keywords