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Abstract #2423

Diffusion Tensor Imaging Correlates of Cognitive Impairment and Fatigue in Multiple Sclerosis

Gunja P. Parikh1, Maxim Bester1,2, Mariana Lazar1, James S. Babb1, Hina Jaggi1, Laura Miles1, Robert Grossman1, Matilde Inglese3,4

1Radiology, New York University, New York, NY, United States; 2Neuroradiology, Eppendorf-Hamburg University, Hamburg, Germany; 3Radiology , New York University, New York, NY, United States; 4Neurology, New York University, New York, NY, United States

Diffusion tensor tractography provides the possibility to reconstruct fiber bundles and to focus on regions that might play a major role in the development of clinical deficits in patients with multiple sclerosis (MS). We used tractography to determine whether tissue damage in the corpus callosum (CC) and in the anterior-thalamic tracts (AT) is associated with cognitive dysfunction and fatigue in patients with benign MS (BMS) and clinically isolated syndrome (CIS). Differences from controls were observed in the CC and AT tracts of BMS and CIS patients. A significant association was found between DTI metrics in the CC and cognitive deficits.