Huiling Peng1, Joseph Mettenburg2,
Avi Snyder1, David Clifford1, Tammie Benzinger2,
Beau Ances3
1Neurology, Washington University in
St. Louis, St. Louis, MO, United States; 2Radiology, Washington
University in St. Louis, St. Louis, MO, United States; 3Neurology,
Washington University in St. Louis, St. Louis, MO , United States
HIV
can lead to chronic inflammation. We investigated the relationship between
aging and HIV status and white matter integrity using DTI in four groups of
participants (HIV younger (20-25 years old) (n=8), HIV- older (50-65 years
old) (n=12), HIV+ younger (20-25 years old) (n=9), and HIV+ older (50-65
years old) (n=9)). Regions-of-interest corresponding to the genus, middle,
and splenium were selected. HIV- older subjects had significant decreases in
mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD)
compared to other all groups. While HIV led to a reduction in DTI measures
these decreases were not significant.
Keywords