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Abstract #2425

Differences in White Matter Fiber Orientation in Three Clinical Groups of Children: Reading Disability, NF-1 and Reading Disability, and Controls

Daniel Jon Peterson1, Sheryl L. Rimrodt2,3, Laurie E. Cutting4

1Developmental Cognitive Neurology, The Kennedy Krieger Institute, Baltimore, MD, United States; 2Division of Developmental Medicine, Children's Hospital at Vanderbilt, Nashville, TN, United States; 3Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD, United States; 4Kennedy Center for Research and Development, Vanderbilt University, Nashville, TN, United States

DTI was used to investigate differences in white matter fiber orientation between three groups: children with reading disability (RD), children with neurofibromatosis type 1 and reading disability (NF1+RD), and typically developing controls. A voxel-wise statistical test that detects differences in fiber orientation revealed bilateral differences in the anterior limb of the internal capsule. In this region, the fiber orientation of controls and RD subjects were similar, while those of the NF1+RD subjects clearly differed, with minimal overlap.