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Abstract #2426

Voxel-Based Morphometric Analysis of Brain Volumetry and Diffusivity in Hepatitis C

Manoj Kumar Sarma1, Rajakumar Nagarajan1, Charles H. Hinkin2, Steven A. Castellon2, Jason P. Smith, Homayoon Khanlou3, Laveeza Bhatti3, Jonathan Truong4, E Singer5, Jiah Jang6, Michelle Kim6, Gabe Waterman6, Rakesh Kumar Gupta7, Michael Albert Thomas1

1Radiological Sciences, UCLA, Los Angeles, CA, United States; 2Psychiatry and Biobehavioral Sciences, UCLA School of Medicine and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States; 3AIDS Healthcare Foundation, Los Angeles, CA, United States; 4Kaiser Permanente, Lancaster, CA, United States; 5Neurology, UCLA School of Medicine, Los Angeles, CA, United States; 6VA West Los Angeles Healthcare System, Los Angeles, CA, United States; 7Radiological Sciences, SGPGIMS, Lucknow, UP, India

We investigated mean diffusivity (MD) and fractional anisotropy (FA) value changes along with white matter and gray matter volume in patients with hepatitis C compared to healthy controls using voxel based morphometry (VBM). Extensive increased MD values were observed in bilateral frontal gray and white matter, bilateral external capsule, temporal white matter, and right occipital gray matter. FA values decreased in the corpus callosum, right frontal and occipital white matter. Widespread gray matter volume reduction was seen in the frontal, parietal and temporal regions. White matter volume decreases were observed in the right frontal, corpus callosum and mid brain.