Manoj Kumar Sarma1, Rajakumar Nagarajan1,
Charles H. Hinkin2, Steven A. Castellon2, Jason P.
Smith, Homayoon Khanlou3, Laveeza Bhatti3, Jonathan
Truong4, E Singer5, Jiah Jang6, Michelle Kim6,
Gabe Waterman6, Rakesh Kumar Gupta7, Michael Albert
Thomas1
1Radiological Sciences, UCLA, Los
Angeles, CA, United States; 2Psychiatry and Biobehavioral
Sciences, UCLA School of Medicine and VA Greater Los Angeles Healthcare
System, Los Angeles, CA, United States; 3AIDS Healthcare
Foundation, Los Angeles, CA, United States; 4Kaiser Permanente,
Lancaster, CA, United States; 5Neurology, UCLA School of Medicine,
Los Angeles, CA, United States; 6VA West Los Angeles Healthcare
System, Los Angeles, CA, United States; 7Radiological Sciences,
SGPGIMS, Lucknow, UP, India
We
investigated mean diffusivity (MD) and fractional anisotropy (FA) value
changes along with white matter and gray matter volume in patients with
hepatitis C compared to healthy controls using voxel based morphometry (VBM).
Extensive increased MD values were observed in bilateral frontal gray and
white matter, bilateral external capsule, temporal white matter, and right
occipital gray matter. FA values
decreased in the corpus callosum, right frontal and occipital white matter.
Widespread gray matter volume reduction was seen in the frontal, parietal and
temporal regions. White matter volume decreases were observed in the right
frontal, corpus callosum and mid brain.
Keywords