Meeting Banner
Abstract #2428

Comparison of Limbic Regions FA Using Tractography-Defined ROIs in AD and MCI

Darryl H. Hwang1, Sinchai Tsao1, Manbir Singh1

1Radiology and Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

The limbic regions appear to be affected by mild cognitive impairment (MCI) and Alzheimer Disease (AD). We use normalized tractography to objectively isolate the fornix and cingulum in a common template space for a voxel-based analysis of FA changes among normal control, MCI, and AD populations. The results show FA change propagation from normals to MCI to AD with more changes in the right hemisphere, which is consistent with previous reports.