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Abstract #2429

Axial and Radial Diffusivity Measures Detect Brain Tissue Injury in Heart Failure Patients

Rajesh Kumar1, Mary A. Woo2, Paul M. Macey2,3, Gregg C. Fonarow4, Michele A. Hamilton4, Ronald M. Harper1,3

1Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 2School of Nursing, UCLA, Los Angeles, CA, United States; 3Brain Research Institute, UCLA, Los Angeles, CA, United States; 4Cardiology, UCLA, Los Angeles, CA, United States

Heart failure (HF) patients show injury in multiple brain sites, which may represent axonal or myelin injury, or both; however, the nature of the injury is unclear. We assessed axial and radial diffusivity measures in HF, which show axonal and myelin changes, respectively. Axonal injury with reduced axonal density or caliber appeared in internal capsule and cerebellar regions, and reduced myelin in temporal and frontal areas. Other brain sites, including internal capsule and dorsomedial medulla showed myelin and axonal injury. The processes contributing to tissue injury in different brain regions are unknown, but may include ischemic/hypoxic or inflammatory processes.