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Abstract #2431

Connection Between Bilateral Superior Temporal Gyrus in Schizophrenia: A Preliminary Diffusion Tensor Imaging Study

Hsiao Piau Ng1,2, Marek Kubicki1,3, Doug Terry1, Paula Pelavin1, Andrew Rausch1, Martha E. Shenton1,3

1Psychiatry Neuroimaging Lab, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; 2Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, -, Singapore; 3Clinical Neuroscience Division, VA Boston Healthcare System, Harvard Medical School, Brockton, MA, United States

In this study, the connection between the bilateral STGs in normal controls (NC) and schizophrenics (SZ) is investigated using DTI measures, namely FA, mode and trace. The connection was obtained from whole-brain streamline tractography using STGs white matter as ROIs. By dividing the connection into three sub-regions (Left, Corpus Callosum and Right) and comparing the computed DTI measures of NC and SZ, we found statistically significant differences in mean FA and mode in the Right region, with NC having greater values. This study paves the way for further localization of the differences in STGs connection between NC and SZ.