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Abstract #2432

Compromised Frontal Callosal Connectivity in Unmedicated Obsessive-Compulsive Disorder: A Quantitative Diffusion Tractography Study

Jungsu S. Oh1,2, Joon Hwan Jang2, Wi Hoon Jung3, Chi-Hoon Choi4, Jung-Seok Choi5, Do-Hyung Kang5, Jun Soo Kwon2

1Brain Korea 21 Division of Human Life Science, Seoul National University, Seoul, Korea, Republic of; 2Psychiatry, Seoul National University College of Medicine, Seoul, Korea, Republic of; 3Interdisciplinary Program in Brain Science, Seoul National University, Seoul, Korea, Republic of; 4Radiology, National Medical Center, Seoul, Korea, Republic of; 5Neuropsychiatry, Seoul National University Hospital, Seoul, Korea, Republic of

Delineating frontostriatal network-related white matter tracts into dorsal/ventral pathways is of particular interest in obsessive-compulsive disorder (OCD) studies. Hence we aim to investigate fractional anisotropy (FA) of dorsal/ventral projections of callosal fibers in OCD on the basis of quantitative diffusion tractography analysis using Brodmann ROI approach and tract parameterization. We found significant FA decreases in callosal fibers of OCD in both DLPFC/OFC projections, benefitting from function/region-specific tractography analysis. Thus we validated well-known abnormalities in these networks of OCD. In particular, DLPFC-specific callosal fiber integrity was first revealed by the function/region-sensitivity of the present methods (not found by previous methods).