Jungsu S. Oh1,2, Joon Hwan Jang2,
Wi Hoon Jung3, Chi-Hoon Choi4, Jung-Seok Choi5,
Do-Hyung Kang5, Jun Soo Kwon2
1Brain Korea 21 Division of Human Life
Science, Seoul National University, Seoul, Korea, Republic of; 2Psychiatry,
Seoul National University College of Medicine, Seoul, Korea, Republic of; 3Interdisciplinary
Program in Brain Science, Seoul National University, Seoul, Korea, Republic
of; 4Radiology, National Medical Center, Seoul, Korea, Republic
of; 5Neuropsychiatry, Seoul National University Hospital, Seoul,
Korea, Republic of
Delineating
frontostriatal network-related white matter tracts into dorsal/ventral
pathways is of particular interest in obsessive-compulsive disorder (OCD)
studies. Hence we aim to investigate fractional anisotropy (FA) of
dorsal/ventral projections of callosal fibers in OCD on the basis of
quantitative diffusion tractography analysis using Brodmann ROI approach and
tract parameterization. We found significant FA decreases in callosal fibers
of OCD in both DLPFC/OFC projections, benefitting from function/region-specific
tractography analysis. Thus we validated well-known abnormalities in these
networks of OCD. In particular, DLPFC-specific callosal fiber integrity was
first revealed by the function/region-sensitivity of the present methods (not
found by previous methods).
Keywords