Abstract #2433

A DTI-Based Assessment of the Changes in the White Matter in Opioid Addict Patients: A Parcellation Based Approach

Nasim Maleki¹, Jaymin Upadhyay¹, Jennifer Potter², Roger Weiss, Lino Becerra^1,3, David Borsook¹

¹PAIN Group, McLean Hospital, Harvard Medical School, Belmont, MA, United States; ²Division of Alcohol and Drug Abuse, Dept. of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, United States; ³Martinos Center, Massachusetts General Hospital, Charlestown, MA, United States

White matter abnormalities in a cohort of prescription opioid dependent subjects (vs. demographically matched subjects) are assessed by combining the parcellated structural and DTI data. Our results show that there are significant changes in white matter in the patient group in the form of reduced fractional anisotropy. The approach used in this study to evaluate white matter integrity has the major advantage of taking individual anatomical differences into account for DTI analysis.