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Abstract #2445

Trimodal Imaging and Brain Plasticity: MR Diffusion Tensor Imaging Supplements Simultaneously Acquired FET-PET and MP-RAGE of Human Brain Tumour Imaging

N. Jon Shah1,2, Irene Neuner1,2, Joachim Bernhard Maria Kaffanke1, Yuliya Kupriyanova1, Karl-Joseph Langen1, Hans Herzog1

1Institute of Neurosciences and Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH, 52425 Juelich, Germany; 2Faculty of Medicine, Department of Neurology, RWTH Aachen University, 52074 Aachen, Germany

PET imaging is well established for the diagnosis of brain tumours. Its metabolic specificity delivers valuable information about the malignancy and the extent of tumour tissue. Tumour growth forces the brain to reorganize itself to compensate for the lost areas. It has been shown that DTI is a valuable tool to demonstrate the plasticity of the brain and it therefore offers information about the reorganization caused by tumour growth as well as surgical intervention. The acquisition of trimodal PET, MP-RAGE and DTI data on an MR-PET hybrid scanner, capable of simultaneous MR and PET, to investigate plasticity and reorganisation in human brain tumours is demonstrated.