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Abstract #2447

Pre-Surgical Mapping Using Magnetoencephalography and Diffusion Tensor Tractography Reveals a Case of Neuroplasticity

Nadia CF Scantlebury1, William Gaetz2, Elysa Widjaja, James Rutka3, Eric Bouffet4, Conrad Rockel1, Don Mabbott1

1Program in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Biomagnetic Imaging Laboratory, Children's Hospital of Philadelphia, Philadelphia, PA; 3Neurosurgery, The Hospital for Sick Children; 4Haemotology/Oncology, The Hospital for Sick Children

We used combined magnetoencephalography (MEG) and Diffusion Tensor Imaging (DTI) tractography methods to delineate the cortico-spinal tracts (CSTs) of an 11-year old female who presented with an arteriovenous malformation (AVM). Concurrent MEG-DTI techniques revealed a case of cerebral plasticity, whereby motor function of the patient remained intact despite the contra-lateral displacement of her CST by the AVM. These data support the use of the functional activation as a seed for launching neural tracts during pre-surgical evaluation in children. Moreover, these findings demonstrate that using a concurrent MEG-DTI approach to delineate CSTs is invaluable when evaluating plasticity in the developing brain.