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Abstract #2481

Diffusion Weighted and Dynamic Contrast Enhanced MRI in Evaluation of Treatment Effects During Neoadjuvant Chemotherapy in Breast Cancer Patients

Line R. Jensen1, Benjamin Garzon1, Mariann G. Heldahl1, Tone F. Bathen1, Pl E. Goa1, Steinar Lundgren1,2, Ingrid S. Gribbestad1

1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Department of Oncology, St. Olavs University Hospital, Trondheim, Norway

The purpose of this study was to use MRI for early evaluation of treatment effects in breast cancer patients undergoing neoadjuvant chemotherapy, and to identify MRI parameters at 3T that correlate to treatment response. In addition, the reproducibility of diffusion weighted MRI was assessed. The ADC values from two baseline examinations showed good reproducibility, with ICC of 0.84. The best predictors of pathologic treatment response were the change in the longest diameter measured on MRI, followed by mean and skewness of ADC, and Ktrans entropy.