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Abstract #2483

Influence of Spatial Heterogeneity on the Diagnostic Accuracy of DCE-MRI in Breast Tumor Characterization

Endre Grvik1, Kjell-Inge Gjesdal2, Kathinka Kurz Dhli3, Atle Bjrnerud4

1University of Oslo, Oslo, Norway; 2Sunnmre MR-klinikk, Aalesund, Norway; 3Stavanger University Hospital, Stavanger, Norway; 4Rikshospitalet University Hospital, Oslo, Norway

This study investigates the influence of spatial heterogeneity on the diagnostic accuracy of DCE-MRI in breast tumor characterization. This is done by comparing the lesions VOI 50th-percentile versus VOI 95th-percentile values for a defined set of pharmacokinetic parameters, based on their ability for differentiating between malignant and benign lesions. Our results suggest that a significant improvement in diagnostic accuracy can be obtained by identifying the 5% region indicating the highest malignancy in the defined tumor VOI.