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Abstract #2495

BOLD Imaging of Compressed Breast Hemodynamics

Stefan Alexandru Carp1, Azma Mareyam1, Lawrence Wald1, David Alan Boas1

1Radiology, Massachusetts General Hospital, Charlestown, MA, United States

External compression induced hemodynamic changes in the breast have recently been investigated as potential biomarkers of breast cancer. Using fast diffuse NIR spectroscopy our group has demonstrated the non-invasive estimation of breast tissue blood flow and oxygen consumption. Consequently, we have designed an integrated MRI-optical breast compression platform for simultaneous acquisition of MR and optical images. MR scans provide structural prior information for optical reconstructions, as well as hemodynamic (BOLD) images for cross-validation against optically measured deoxy-hemoglobin. We describe the MRI breast compression platform and present initial results demonstrating contrast between the BOLD signal evolution in fibro-glandular vs. adipose tissue.