Anna Louise Babin1,2, Catherine Cannet1,
Christelle Gerard1, Clive P. Page3, Nicolau Beckmann1
1Global Imaging Group, Novartis
Institutes for BioMedical Research, Basel, BS, Switzerland; 2Sackler
Institute of Pulmonary Pharmacology, Kings College, London, SE1 1UL, United
Kingdom; 3Sackler Institute of Pulmonary Pharmacology, King's
College, London, SE1 1UL, United Kingdom
Micro-CT
has been shown to be useful in characterizing anatomical changes related to
lung fibrosis models in rats. However, radiation doses are an issue both in
the clinics and in experimental studies, and repetitive measurements are
limited. In the present work, we show that proton MRI can be used to follow
longitudinally in spontaneously breathing rats the development of structural
changes related to lung fibrosis induced by bleomycin administration, and
thus MRI represents a non-X ray based imaging alternative to study
experimental fibrosis.
Keywords