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Abstract #2520

A Novel Method Using Proton MRI and Image Registration to Investigate Relative Regional Pulmonary Compliance

Alexandra Rose Morgan1,2, Geoff J.M. Parker1,2, Marietta L.J. Scott3, Tim F. Cootes1,2, Josephine H. Naish1,2

1Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, The University of Manchester, Manchester, United Kingdom; 2The Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom; 3AstraZeneca, Alderley Park, Macclesfield, United Kingdom

Current diagnosis methods in chronic obstructive pulmonary disease (COPD) are not capable of examining regional pathological changes in mechanical properties. We have developed a method for investigating relative regional pulmonary compliance using proton magnetic resonance imaging (MRI). A 2D half-Fourier acquired single-shot turbo spin-echo (HASTE) sequence was optimised for lung imaging. A mesh-based group-wise affine image registration was applied to images ordered according to respiratory cycle position. Information from the registration allowed relative regional compliance measures to be extracted and mapped over the lung. Maps show differences between healthy volunteers and COPD patients and can indicate likely regions of disease.