Meeting Banner
Abstract #2521

Quantification of Bleomycin Induced Lung Injury by Means of 1H Magnetic Resonance Elastography

Kiaran P. McGee1, Richard L. Ehman1, Rolf D. Hubmayr2, David L. Levin1, Mary Breen3, Debora Rasmussen2, Yogesh K. Mariappan1

1Radiology, Mayo Clinic and Foundation, Rochester, MN, United States; 2Pulmonology & Critical Care, Mayo Clinic and Foundation, Rochester, MN, United States; 3College of Arts and Sciences, Boston College, Boston, MA, United States

Interstitial lung disease (ILD) induced end stage fibrosis is a multi phase process that includes presence of an exudate followed by either edema clearance or organization of the space filling material and fibrosis. We have applied magnetic resonance elastography (MRE) to determine if this method can differentiate between normal and those processes associated with ILD. MRE estimates of shear modulus increased following lung injury when compared to an air-filled lung suggesting that lung injury-induced restructuring of lung parenchyma results in changes to the intrinsic mechanical properties of the lung and that these changes can be quantitated with MRE.