Junichi Tokuda1, Hatsuho Mamata1, Ritu R. Gill1, Samuel Patz1, Nobuhiko Hata1, Robert E. Lenkinski2, David J. Sugarbaker3, Hiroto Hatabu1
1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 3Department of Surgery, Brigham and Women's Hospital, Boston, MA, United States
We demonstrate perfusion analysis of solitary pulmonary nodule based on free-breath DCE MRI. In DCE MRI studies, the kinetics of signal variation at lesions following the administration of the contrast agent is analyzed from time-intensity curve. Thus, it is crucial to measure the signal intensity at the corresponding regions in each frame in the time-series of images for accurate signal intensity curve analysis. However, the respiratory motion of the subjects during scans causes misalignment of anatomical regions among the frames resulting inaccuracy of time-intensity curve. In this paper, we compare perfusion analyses based on motion-compensated MRI data and manual measurement.