Junichi Tokuda1, Hatsuho Mamata1,
Ritu R. Gill1, Samuel Patz1, Nobuhiko Hata1,
Robert E. Lenkinski2, David J. Sugarbaker3, Hiroto
Hatabu1
1Department of Radiology, Brigham and
Women's Hospital, Boston, MA, United States; 2Department of
Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 3Department
of Surgery, Brigham and Women's Hospital, Boston, MA, United States
We
demonstrate perfusion analysis of solitary pulmonary nodule based on
free-breath DCE MRI. In DCE MRI studies, the kinetics of signal variation at
lesions following the administration of the contrast agent is analyzed from
time-intensity curve. Thus, it is crucial to measure the signal intensity at
the corresponding regions in each frame in the time-series of images for
accurate signal intensity curve analysis. However, the respiratory motion of
the subjects during scans causes misalignment of anatomical regions among the
frames resulting inaccuracy of time-intensity curve. In this paper, we
compare perfusion analyses based on motion-compensated MRI data and manual
measurement.
Keywords