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Abstract #2529

Hyperpolarized Xenon-129 Ventilation MRI: Preliminary Results in Normal Subjects and Patients with Lung Disease

Talissa A. Altes1, John P. Mugler1, Isabel M. Dregely2, Stephen Ketel3, Iulian C. Ruset2,3, Eduard E. de Lange1, F William Hersman2,3, Kai Ruppert1

1Radiology, University of Virginia, Charlottesville, VA, United States; 2Physics, University of New Hampshire, Durham, NH; 3Xemed, LCC, Durham, NH

The purpose of this study was to assess the feasibility and currently achievable quality of hyperpolarized xenon-129 ventilation (spin density) MRI in normal subjects (n=7) and patients with asthma (n=5), chronic obstructive pulmonary disease (COPD) (n=4), cystic fibrosis (CF) (n=1), and sickle cell disease (SCD) (n=1). As seen previously with helium, the normal subjects had homogeneous ventilation with few if any ventilation defects. Focal ventilation defects were found in all patients with obstructive lung diseases. Qualitatively the hyperpolarized xenon-129 ventilation images are similar although not identical to previously acquired hyperpolarized helium-3 ventilation images in different patients with similar disease states.