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Abstract #2528

Comparison of Hyperpolarized 3He and 129Xe for Measurement of Absolute Ventilated Lung Volume of Rat Lungs

Matthew S. Fox1,2, Alexei Ouriadov1, William Dominguez-Viqueira1,3, Marcus Couch1,2, Giles E. Santyr1,3

1Imaging, Robarts Research Institute, London, Ontario, Canada; 2Physics and Astronomy Dept, University of Western Ontario, London, Ontario, Canada; 3Medical Biophysics, University of Western Ontario, London, Ontario, Canada

Magnetic Resonance (MR) imaging using hyperpolarized noble gases (HNG) 3He and 129Xe provides a non-invasive approach for probing both lung function and structure. Measurement of ventilated lung volumes are useful for characterizing chronic obstructive pulmonary disease, quantifying the diffusing capacity of xenon and may be useful in measuring lung mechanics such as compliance. The objective of this work was to perform 3D MR imaging in rats under similar ventilation conditions and compare measured ventilated volumes obtained from the two gases in an effort to show that 129Xe is just as accurate as 3He which has already been validated by microCT.