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Abstract #2537

On the Relationship Between 3He ADC and Lung Morphometrical Parameters

Alexander L. Sukstanskii1, James D. Quirk1, Jason C. Woods1,2, David S. Gierada1, Barbara A. Lutey3, Mark S. Conradi2, Dmitriy A. Yablonskiy1,2

1Radiology, Washington University, St. Louis, Misssouri, United States; 2Physics, Washington University, St. Louis, MO, United States; 3Internal Medicine, Washington University, St. Louis, MO, United States

The apparent diffusion coefficient (ADC) of hyperpolarized 3He gas in lungs increases in emphysema and can serve as a biomarker of the disease progression. It is not clear, however, how ADC relates to lung microstructure. In the present communication, using 3He-based in vivo lung morphometry technique, we demonstrate that ADC and a standard histological parameter mean chord length (Lm) reflect lung microstructure parameters in different ways. As a result, a there is no unique relationship between ADC and Lm. At the same time, 3He-based lung morphometry allows quantification of the lung microstructure in terms of Lm, surface-to-volume ratio and other standard histological parameters.