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Abstract #2538

Modelling Non-Gaussian 3He Diffusion Signal Behaviour Using a Fractional Dynamics Approach

Juan Parra-Robles1, Salma Ajraoui1, Jim M. Wild1

1University of Sheffield, Sheffield, United Kingdom

Diffusion of 3He gas in the lung has been shown to deviate from Gaussian behaviour. Cylinder model and diffusional kurtosis have been previously used to quantify non-Gaussian signals. In this work the diffusion stretched-exponential model is used as a new approach to model the non-Gaussian behaviour. The results obtained demonstrate that the anomalous diffusion stretched-exponential model fits well the behaviour of the 3He lung MR signal. This model can potentially provide valuable information about lung microstructure at different length scales.