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Abstract #2561

Quantitative Assessment of Alveolar Recruitment with Hyperpolarized Gas MRI

Kiarash Emami1, Masaru Ishii2, Stephen J. Kadlecek1, Jianliang Zhu3, Stephen Pickup1, Yi Xin1, Puttisarn Mongkolwisetwara1, Harrilla Profka1, Rahim R. Rizi1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Otolaryngology, Johns Hopkins University, Baltimore, MD, United States; 3Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States

This study evaluates the preliminary use of HP gas diffusion MRI to assess alveolar recruitment dynamics in a healthy rat model. After a period of ventilation at zero positive end-expiratory pressure (PEEP), recruitment was studied at elevated PEEP and constant tidal volume. After recruitment, it was found that regional ADC values initially diminished and consistently recovered with the removal of elevated PEEP. It is therefore proposed that before recruitment, accumulated alveolar collapse causes the over-extension of active alveoli (high ADC); after recruitment, the fixed tidal volume is shared by the greater number of recruited alveoli (corresponding to decreased ADC).