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Abstract #2571

Hyperpolarized 3He Magnetic Resonance Image Registration Tools for Longitudinal and Multi-Modality Studies

Lindsay Mathew1,2, Usaf Aladl1, Aaron Fenster1,2, Grace Parraga1,2

1Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; 2Medical Biophysics, The University of Western Ontario, London, Ontario, Canada

Hyperpolarized 3He MRI has shown promise as a treatment planning tool for lung cancer. Current barriers to the application of this technology include a lack of accurate image registration techniques. Registration of longitudinally acquired 3He MRI scans and 3He MRI to CT will allow for both detection of regional changes in lung function, and determination of ventilation defect pathology. In this study accuracy and variability of 3He MRI registration techniques were evaluated from a dataset consisting of subjects scanned longitudinally at our center. The Fiducial Localization Error and Fiducial Registration Error were evaluated as metrics of registration accuracy and precision.