Abstract #2571

Hyperpolarized 3He Magnetic Resonance Image Registration Tools for Longitudinal and Multi-Modality Studies

Lindsay Mathew^1,2, Usaf Aladl¹, Aaron Fenster^1,2, Grace Parraga^1,2

¹Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; ²Medical Biophysics, The University of Western Ontario, London, Ontario, Canada

Hyperpolarized ³He MRI has shown promise as a treatment planning tool for lung cancer. Current barriers to the application of this technology include a lack of accurate image registration techniques. Registration of longitudinally acquired ³He MRI scans and ³He MRI to CT will allow for both detection of regional changes in lung function, and determination of ventilation defect pathology. In this study accuracy and variability of ³He MRI registration techniques were evaluated from a dataset consisting of subjects scanned longitudinally at our center. The Fiducial Localization Error and Fiducial Registration Error were evaluated as metrics of registration accuracy and precision.