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Abstract #2572

Quantitative Evaluation of Hyperpolarized Gas Retention in the Lungs During Time Resolved 3D MRI

Jionghan Dai1, Eric Peterson2, James H. Holmes3, Sean B. Fain1,4

1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States; 2Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States; 3Applied Science Lab, GE Healthcare, Madison, WI, United States; 4Radiology, University of Wisconsin - Madison, Madison, WI, United States


This work seeks to provide a quantitative regional measure of gas retention in the lung. A 3D multi-echo projection acquisition is used, accompanied with an iterative HYPR reconstruction to provide a time resolved 3D image series. Post exhalation images are used to generate quantitative maps of gas retention. To summarize, this work presents potential new methods to characterize the gas retention under forced exhalation using hyperpolarized noble gas MRI.

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